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Worthington, Massachusetts, was named after Colonel John Worthington of Springfield, Massachusetts, one of the original purchasers from the Massachusetts Bay Province in 1762. Incorporated as a town in 1768, Worthington is located on the western edge of Hampshire County and is considered one of the "hill towns" of western Massachusetts. Like other agricultural towns in the area, once booming Worthington, suffered a long decline in population as agricultural economics changed during the 1800s.